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norskBlar i forfatter "Sørbye, Sveinung"
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13-Type HPV DNA Test versus 5-Type HPV mRNA Test in Triage of Women Aged 25–33 Years with Minor Cytological Abnormalities–6 Years of Follow-Up
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-25)Background: A specific, cost-effective triage test for minor cytological abnormalities is essential for cervical cancer screening among younger women to reduce overmanagement and unnecessary healthcare utilization. We compared the triage performance of one 13-type human papillomavirus (HPV) DNA test and one 5-type HPV mRNA test. Methods: We included 4115 women aged 25–33 years with a screening ... -
Can an inadequate cervical cytology sample in ThinPrep be converted to a satisfactory sample by processing it with a SurePath preparation?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-08-22)Background: The Norwegian Cervical Cancer Screening Program recommends screening every 3 years for women between 25 and 69 years of age. There is a large difference in the percentage of unsatisfactory samples between laboratories that use different brands of liquid-based cytology. We wished to examine if inadequate ThinPrep samples could be satisfactory by processing them with the SurePath ... -
Clinical characterization of Helicobacter pylori infected patients 15 years after unsuccessful eradication
(Journal article; Tidsskriftartikkel, 2020-09-23)<i>Background and aims</i> - Patients that have failed therapy for Helicobacter pylori (H. pylori) infection are incompletely characterized. The aim of this study was to characterize a H. pylori treatment resistant cohort compared to the cohorts of newly diagnosed, earlier eradicated and non-infected.<p> <p><i>Material and methods</i> - Patients were selected from routine referrals to the Endoscopy ... -
Discovery and validation of mucosal TNF expression combined with histological score-a biomarker for personalized treatment in ulcerative colitis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-02)<i>Background</i> - There are no accurate markers that can predict clinical outcome in ulcerative colitis at time of diagnosis. The aim of this study was to explore a comprehensive data set to identify and validate predictors of clinical outcome in the first year following diagnosis.<p> <p><i>Methods</i> - Treatment naive-patients with ulcerative colitis were included at time of initial diagnosis ... -
Intestinal inflammatory profile shows increase in a diversity of biomarkers in irritable bowel syndrome
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-24)Background: It has been proposed that irritable bowel syndrome (IBS) is a low-grade mucosal inflammatory disease. <p> <p>Objective: To characterize the intestinal inflammatory profile in IBS patients with or without fructose intolerance.<p> <p>Design: Patients referred to colonoscopy with IBS complaints were screened for participation. IBS patients diagnosed according to the Rome II criteria ... -
May Women with a Negative Co-Test at First Follow-Up Visit Return to 3-Year Screening after Treatment for Cervical Intraepithelial Neoplasia?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-08)Background: The Norwegian Cervical Cancer Screening Programme recommends that women treated for cervical intraepithelial neoplasia (CIN) only be returned to 3-year screening after receiving two consecutive negative co-tests, 6 months apart. Here we evaluate adherence to these guidelines and assessed the residual disease, using CIN3+ as the outcome. Methods: This cross-sectional study comprised ... -
Population-based screening for celiac disease reveals that the majority of patients are undiagnosed and improve on a gluten-free diet
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-25)The impact of a gluten-free diet (GFD) on screen-detected celiac disease (CD) is currently ambiguous. We aimed to identify the population-based prevalence of undiagnosed adult CD and examine the impact of a GFD on screen-detected CD. In total, 12,981 adults participated in a population-based health study in Tromsø, Norway. Participants with increased levels of anti-tissue transglutaminase-2 IgA ... -
Prediction of long-term remission in patients following discontinuation of anti-TNF therapy in ulcerative colitis: a 10 year follow up study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-16)Background - The long-term outcomes of Ulcerative colitis (UC) after discontinuation of biological therapy are largely unknown. There is also a lack of accurate and validated markers that can predict outcome after withdrawal accurately. The aims of this study were to describe the long-term outcomes in UC patients following cessation of anti-TNF therapy and explore potential biomarkers as an approach ... -
Quality control of cervical cytology using a 3-type HPV mRNA test increases screening program sensitivity of cervical intraepithelial neoplasia grade 2+ in young Norwegian women-A cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-05)Within 2021, Norway intends to complete implementation of HPV DNA-based primary screening for cervical cancer for women 34–69 years, while continue cytology-based screening for women 25–33 years. Over the recent years, the incidence of cervical cancer has increased by 30% among women younger than 40 years. In this subset of women, nearly 30% were diagnosed with a normal smear, as most recent smear, ... -
Recurrent disease after treatment for cervical intraepithelial neoplasia-The importance of a flawless definition of residual disease and length of follow-up
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-09)Objective - To evaluate adherence to national guidelines for follow-up, and assess residual and recurrent disease after treatment for cervical intraepithelial neoplasia grade 2 or worse (CIN2+).<p> <p>Study design - In a case-series design women aged 25–69 years treated for primary CIN2+ in 2006–2011 (n = 752) were followed through August 9, 2019 for residual or recurrent disease, i.e., CIN2+ ... -
Risk of Intraepithelial Neoplasia Grade 3 or Worse (CIN3+) among Women Examined by a 5-Type HPV mRNA Test during 2003 and 2004, Followed through 2015
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-08)<p><i>Background:</i> The study’s purpose was to evaluate the performance of a five-type HPV mRNA test to predict cervical intraepithelial neoplasia grade 3 or worse (CIN3+) during up to 12 years of follow-up. <p><i>Methods:</i> Overall, 19,153 women were recruited by gynecologists and general practitioners in different parts of Norway between 2003 and 2004. The study population comprised 9582 ... -
Transcriptional signatures that define ulcerative colitis in remission
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-23)<i>Background</i> - This study addresses whether existing specific transcriptional profiles can improve and support the current status of the definition of ulcerative colitis (UC) remission apart from the existing endoscopic, histologic, and laboratory scoring systems. For that purpose, a well-stratified UC patient population in remission was compared to active UC and control patients and was ... -
Ulcerative colitis: Functional analysis of the in-depth proteome
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-29)<p><i>Background - </i>Ulcerative colitis (UC) is one major form of inflammatory bowel disease. The cause and the pathophysiology of the disease are not fully understood and we therefor aim in this study to identify important pathophysiological features in UC from proteomics data. <p><i>Methods - </i>Colon mucosa biopsies from inflamed tissue of untreated UC patients at diagnosis and from healthy ...
